Amy leads the Cognitive Health Initiative at Monash University in Melbourne, Australia. She heads Cognitive Neurology Services and dementia trials at Melbourne Health and Eastern Health. Her research focuses on improving the diagnostic odyssey for people with dementia and understanding vascular contributions to late-life brain health. Her vision is brain health for all: developing measures of brain health and identifying opportunities for brain health promotion.

She sits on the editorial boards of Neurology, Stroke and International Journal of Stroke and is on the Science Committee for the American Academy of Neurology and the Vascular Brain Health Institute in Bordeaux, France. She was the first woman appointed as an Honorary Medical Advisor for Dementia Australia, the inaugural President of the Australasian Cognitive Neurology Association, and the inaugural Chair for the Australian Chapter of the Organization of Human Brain Mapping In 2022 she was awarded the Mervyn Eadie Prize, the peak mid-career award for ANZ academic neurologists.